Peptides

[Arg6]-beta-Amyloid (1-40), England Mutation - 0.5 mg

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  • Cat.Number : AS-63321
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Several mutations in the beta amyloid precursor gene cause autosomal dominant Alzheimer's Disease in a number of kindreds. Among them, the English mutation, with His at position 6 replaced with Arg, was reported to accelerate the kinetics of oligomers formation which act as fibril seeds and are more toxic to cultured neuronal cells.

Specifications

Chemistry
Sequence one letter code
  • DAEFRRDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV
Sequence three letter code
  • H-Asp-Ala-Glu-Phe-Arg-Arg-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH
CAS registry number
  • 1802084-26-9
Molecular Formula
  • C194H300N54O58S
Molecular Mass/ Weight
  • 4348,9
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • ≥ 95%
Storage & stability
Form
  • Lyophilized
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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Citations

Test-2

Eurogentec journal . 2025 Oct 14 ; 32 10-25 | DOI : https://Blog

  • Benoît Wolf

test

. 2020 Oct 14 ;

Functional Landscape of PCGF Proteins Reveals Both RING1A/B-Dependent-and RING1A/B-Independent-Specific Activities

Molecular Cell . 2019 Jun 07 ; 74-5 1037-1052.e7 | DOI : 10.1016/j.molcel.2019.04.002

  • Andrea Scelfo
  • Daniel Fernández-Pérez
  • Simone Tamburri
  • Marika Zanottti
  • Elisa Lavarone
  • Monica Soldi
  • Tiziana Bonaldi
  • Karin Johanna Ferrari
  • Diego Pasini